classical dendritic cells

Classical or conventional dendritic cells (cDCs) are highly adept at Ag presentation. Dendritic cells; Hematopoiesis; Ontogeny. Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P. Immunity. cDCs are a heterogeneous cell population that contains two main subsets, named type 1 and type 2 cDCs, arising from divergent ontogenetic pathways and populating multiple lymphoid and non-lymphoid tissues. FOIA Typically, the disease presents with skin lesions (e.g. Xu Y, Jiang D, Hu Y, Li Y, Zhang X, Wang J, Wang Y. Mol Med Rep. 2015 Nov;12(5):6969-75. doi: 10.3892/mmr.2015.4320. Would you like email updates of new search results? National Library of Medicine Transcription factor networks in dendritic cell development. 8600 Rockville Pike Fucikova J, Kepp O, Kasikova L, Petroni G, Yamazaki T, Liu P, Zhao L, Spisek R, Kroemer G, Galluzzi L. Cell Death Dis. 2020 Nov 26;11(11):1013. doi: 10.1038/s41419-020-03221-2. Fms-like tyrosine kinase 3 ligand is required for thymic dendritic cell generation from bone marrow-derived CD117⁺ hematopoietic progenitor cells. Initially defined by their unique T cell activation potential, it became quickly apparent that cDCs would be difficult to distinguish from other phagocyte lineages, by solely relying on marker-based approaches. The present document proposes a nomenclature for these cells and defines 3 types of monocytes (classical, intermediate, and nonclassical monocytes) and 3 types of dendritic cells (plasmacytoid and 2 types of myeloid dendritic cells) in human and in mouse blood. Classical dendritic cells (cDCs) in the intestine can facilitate both T cell-dependent and -independent secretory IgA. Clipboard, Search History, and several other advanced features are temporarily unavailable. Due to the differences in their local environment, two populations may express different genes and potentially carry different functions We used microarrays to compare the gene expression profiles between myeloid dendritic cells and classical dendritic cells in spleen. Epub 2020 Jun 30. Would you like email updates of new search results? Conventional Dendritic Cells (cDCs) Also known as classical dendritic cells (or myeloid dendritic cells), conventional dendritic cells are all the different types of dendritic … Despite the critical role of classical dendritic cells (cDCs) in the initiation of adaptive immune responses, the genetic and phenotypic definition of cDCs remains moot. Identified in mouse spleen for their peculiar shape and capacity to activate naïve lymphocytes (1–3), dendritic cells (DC) are considered the most efficient antigen presenting cells (APC) (3, 4), uniquely able to initiate, coordinate, and regulate adaptive immune responses. Please enable it to take advantage of the complete set of features! Detection of immunogenic cell death and its relevance for cancer therapy. This site needs JavaScript to work properly. FLT3L stimulates the development of classical dendritic cells, but the role of FLT3L-dependent dendritic cells in hypertension requires elucidation. Distinguishing dendritic cells (DCs) from other cells of the mononuclear phagocyte system is complicated by the shared expression of cell surface markers such as CD11c. Epub 2012 May 21. © 2019 Elsevier Inc. All rights reserved. Menu. Figure 1 Generic recipe of classical monocyte-derived dendritic cells (DCs). Epidermal or dermal dendritic cells are found in different forms on and within the skin. Satpathy AT, KC W, Albring JC, Edelson BT, Kretzer NM, Bhattacharya D, Murphy TL, Murphy KM. Bourdely P, Anselmi G, Vaivode K, Ramos RN, Missolo-Koussou Y, Hidalgo S, Tosselo J, Nuñez N, Richer W, Vincent-Salomon A, Saxena A, Wood K, Lladser A, Piaggio E, Helft J, Guermonprez P. Immunity. Epub 2015 Sep 11. Dendritic cells (DCs) are the most efficient and professional antigen-presenting cells of the immune system required for induction and dispersion of immune responses. DCs in mice can be divided into two main types. 2012 Jun 4;209(6):1053-6. doi: 10.1084/jem.20121038. Unable to load your collection due to an error, Unable to load your delegates due to an error. Epub 2011 Sep 15. Classical dendritic cells (cDCs), which exist in the lung in relatively small numbers, are ideally positioned to serve a priming and central role in the immune response during infection/inflammation (5,6). Clipboard, Search History, and several other advanced features are temporarily unavailable. cDCs are a heterogeneous cell population that contains two main subsets, named type 1 and type 2 cDCs, arising from divergent ontogenetic pathways and populating multiple lymphoid and non-lymphoid tissues. Privacy, Help eCollection 2020. J Exp Med. Semin Immunol. © 2019 Elsevier Inc. All rights reserved. Zbtb46 expression distinguishes classical dendritic cells and their committed progenitors from other immune lineages. Conventional type 1 dendritic cells (cDC1s) are recruited into the tumor microenvironment by chemokines such as XCL1 and CCL5, produced by intratumoral natural killer (NK) cells (and potentially other lymphocytes). Unable to load your collection due to an error, Unable to load your delegates due to an error. doi: 10.1016/j.immuni.2020.06.002. Although there appears to be functional homology between mouse and human cDCs, these cells express unique, species-specific markers. Defense against attaching-and-effacing bacteria requires the sequential generation of interleukin 23 (IL-23) and IL-22 to induce protective mucosal responses. 2011 Oct;23(5):388-97. doi: 10.1016/j.smim.2011.08.009. J Exp Med. Dendritic cells; Hematopoiesis; Ontogeny. Epub 2020 Jun 30. Splenic CD8 − CD4 + conventional dendritic cells and CD11c hi CD11b hi lamina propria DCs, also clearly expressed cell surface TLR5. The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34(+) stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin. Classical or conventional DCs (cDCs) are specialized Ag-presenting cells with a characteristic dendritic morphology, high major histocompatibility complex (MHC) class II expression, and a unique capacity for priming naive T cells. Today, cDCs definition increasingly embed their unique ontogenetic features. These types make their way to the lungs, intestines, liver, and kidneys. 8600 Rockville Pike Prevention and treatment information (HHS). Classical dendritic cells as a unique immune cell lineage. Classical dendritic cells (cDCs) are mononuclear phagocytes of hematopoietic origin specialized in the induction and regulation of adaptive immunity. cDCs can also stimulate CD8 + T cells through classical and cross-presentation pathways. In mice, there are two subsets of lymphoid tissue-resident cDCs that have been characterized, CD8 alpha + cDCs and CD11b + cDCs. They are bone marrow and lymph-derived leukocytes or white blood cells. Here, we present recent knowledge on the cellular and molecular pathways controlling the specification and commitment of cDC subsets from murine and human hematopoietic stem cells. Bajana S, Thomas K, Georgescu C, Zhao Y, Wren JD, Kovats S, Sun XH. Classical dendritic cells mediate fibrosis directly via the retinoic acid pathway in severe eye allergy Sarah D. Ahadome, 1,2 Rose Mathew, 1 Nancy J. Reyes, 1 Priyatham S. Mettu, 1 Scott W. Cousins, 1,3 Virginia L. Calder, 2 and Daniel R. Saban 1,3 Accessibility These cells are subsequently exposed to activating factors for maturation and loaded with tumor-associated antigens (TAAs). Front Immunol. Dendritic cells are named after their shape and are not neurons with dendrites, as was thought when first discovered in the late nineteenth century. Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Privacy, Help A growing consensus defines cDCs on multiple criteria including: (1) dependency on the fms-like tyrosine kinase 3 ligand hematopoietic growth factor, (2) development from the common DC bone marrow progenitor, (3) constitutive expression of the transcription factor ZBTB46 and (4) the ability to induce, after adequate stimulation, the activation of naïve T lymphocytes. Augmenting E Protein Activity Impairs cDC2 Differentiation at the Pre-cDC Stage. Here, we present recent knowledge on the cellular and molecular pathways controlling the specification and commitment of cDC subsets from murine and human hematopoietic stem cells. eCollection 2020. Proietto AI, Mittag D, Roberts AW, Sprigg N, Wu L. Cell Mol Immunol. NK cells further secrete the growth factor FLT3L, which supports the survival of cDC1s and might enhance local cDC1 differentiation from DC precursors. Activated classical dendritic cells (cDCs) travel to the T cell areas of secondary lymphoid tissues to stimulate CD4 + T cells through classical antigen presentation on MHC class II. Semin Immunol. In this study, we identified Zbtb46 ( BTBD4 ) as a transcription factor selectively expressed by classical DCs (cDCs) and their committed progenitors but not by plasmacytoid DCs (pDCs), monocytes, macrophages, or other … Europe PMC. Epub 2012 May 21. Careers. Notch2-dependent intestinal CD11b+ cDCs, but not Batf3-dependent CD103+ cDCs, were an obligate source of IL-23 Correspondence should be addressed to K.M.M. Epub 2012 Oct 22. COVID-19 is an emerging, rapidly evolving situation. Epub 2012 Oct 22. 2012 Jun 4;209(6):1053-6. doi: 10.1084/jem.20121038. … Please enable it to take advantage of the complete set of features! FLT3L-deficient (FLT3L-/-) mice that lack classical DCs in the kidney had mean arterial pressures similar to wild-types (WTs) at baseline but had blunted hypertensive responses during 4 … Classical dendritic cells as a unique immune cell lineage. Bethesda, MD 20894, Copyright 2020 Nov 26;11(11):1013. doi: 10.1038/s41419-020-03221-2. 2020 Dec 18;11:577718. doi: 10.3389/fimmu.2020.577718. Here, we focussed on the role of macrophages (MΦ) and dendritic cells (DC). Background The inflammatory infiltrate plays a pivotal role in classical Hodgkin lymphoma (cHL). Within the tumor, cDC1s … In the current study, we find that FLT3L-dependent classical dendritic cells enhance the accumulation of effector memory T lymphocytes in the kidney and cause renal sodium and fluid retention during chronic Ang II infusion. Dendritic cells (DCs) are the most potent professional antigen-presenting cells (APCs) in vivo, capable of both tolerance induction and the initiation of primary T-cell responses. About Europe PMC; Preprints in Europe … Xu Y, Jiang D, Hu Y, Li Y, Zhang X, Wang J, Wang Y. Mol Med Rep. 2015 Nov;12(5):6969-75. doi: 10.3892/mmr.2015.4320. Classical or conventional DCs (cDCs) are specialized Ag-presenting cells with a characteristic dendritic morphology, high major histocompatibility complex (MHC) class II expression, and a unique capacity for priming naive T cells. Monocytes are obtained from the patient’s peripheral blood and cultured with IL-4 and GM-CSF to generate immature DCs. Transcriptional and Functional Analysis of CD1c, NC/K001868/1/National Centre for the Replacement, Refinement and Reduction of Animals in Research/United Kingdom, BB/M029735/1/BB_/Biotechnology and Biological Sciences Research Council/United Kingdom. Plasmacytoid DCs (pDCs) secrete type I interferons (IFN-α/β) in response to viruses. National Library of Medicine Fucikova J, Kepp O, Kasikova L, Petroni G, Yamazaki T, Liu P, Zhao L, Spisek R, Kroemer G, Galluzzi L. Cell Death Dis. 2020 Aug 18;53(2):335-352.e8. Upon Ag capture, cDCs upregulate chemotactic receptors such as CCR7, migrate from tissues into the T cell areas of regional lymphoid organs, secrete … Notch2-dependent classical dendritic cells orchestrate intestinal immunity to attaching-and-effacing bacterial pathogens. Coronavirus: Find the latest articles and preprints Sign in or create an account. Keywords: Methods MΦ and DC infiltration was investigated in 106 cHL specimens using immunohistochemistry and cytokine expression was analyzed in a subset by real-time PCR. We used genetic techniques to deplete specific subsets of classical dendritic cells (cDCs) and analyzed immunity to the A/E pathogen Citrobacter rodentium. Dendritic cells (DCs) are antigen-presenting cells derived from bone marrow precursors and form a widely distributed cellular system throughout the body. Classical dendritic cells are required for dietary antigen–mediated induction of peripheral T reg cells and tolerance. Bajana S, Thomas K, Georgescu C, Zhao Y, Wren JD, Kovats S, Sun XH. J Exp Med. The equivalents of human blood and spleen dendritic cell subtypes can be generated in vitro from human CD34(+) stem cells in the presence of fms-like tyrosine kinase 3 ligand and thrombopoietin. Blastic plasmacytoid dendritic cell neoplasm is a rare type of myeloid cancer in which malignant pDCs infiltrate the skin, bone marrow, central nervous system, and other tissues. Today, cDCs definition increasingly embed their unique ontogenetic features. We found that Notch2 controlled the terminal stage of cDC differentiation. Satpathy AT, KC W, Albring JC, Edelson BT, Kretzer NM, Bhattacharya D, Murphy TL, Murphy KM. 2012 Nov;9(6):446-54. doi: 10.1038/cmi.2012.48. DCs exert immune-surveillance for exogenous and endogenous antigens and the later activation of naive T lymphocytes giving rise to various immunological responses. Detection of immunogenic cell death and its relevance for cancer therapy. Classical dendritic (cDC) cell stimulation of CD4 + T cells and CD8 + T cells. Accessibility Initially defined by their unique T cell activation potential, it became quickly apparent that cDCs would be difficult to distinguish from other phagocyte lineages, by solely relying on marker-based approaches. Keywords: In addition to being potent stimulators/activators of an adaptive immune response DCs can also initiate an innate immune response and even have a role in immune tolerance (Schraml & Sousa 2015).

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