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Shaikh ARK, Ujjan I, Irfan M, Naz A, Shamsi T, Khan MTM, Shakeel M. PeerJ. Epub 2014 Mar 31. TET2 mutated patients had lower CR1 rate and 2-year overall survival than unmutated in non-M(3) patients (P < 0.05). -, Grimwade D, Hills RK. Accessibility Original Article from The New England Journal of Medicine — Genomic Classification and Prognosis in Acute Myeloid Leukemia. Metzeler KH, Maharry K, Radmacher MD, Mrózek K, Margeson D, Becker H, Curfman J, Holland KB, Schwind S, Whitman SP, Wu YZ, Blum W, Powell BL, Carter TH, Wetzler M, Moore JO, Kolitz JE, Baer MR, Carroll AJ, Larson RA, Caligiuri MA, Marcucci G, Bloomfield CD. Epub 2014 Mar 31. Dr. Daver: Yeah. a pooled ORs and 95%CI for…, Prognosis of CN-AML patients with TET2 mutation. TET2 (Ten-Eleven Translocation 2) gene is a member of TET family that can modify DNA through catalyzing the conversion of 5-methylcytosine (5-mC) into 5-hydroxymethylcytosine (5-hmC). 2020 Mar 25;12(6):5031-5047. doi: 10.18632/aging.102928. Acute myeloid leukaemia: recent data on prognostic gene mutations, in relation to stratified therapies for elderly patients. Would you like email updates of new search results? See this image and copyright information in PMC. TET2 mutation was an unfavorable prognostic factor for overall survival (OS: HR = 1.386; P < 0.001) and event-free survival (EFS: HR = 1.594; P = 0.002) in patients with AML. Prognostic significance of Tet methylcytosine dioxygenase 2 (TET2) gene mutations in adult patients with acute myeloid leukemia: a meta-analysis. Guan W, Zhou L, Li Y, Yang E, Liu Y, Lv N, Fu L, Ding Y, Wang N, Fang N, Liu Q, Wang B, Li F, Zhang J, Wang M, Wang L, Jing Y, Li Y, Yu L. Exp Hematol Oncol. We investigated ten–eleven translocation 2 (TET2) mutations in acute myeloid leukemia (AML), their correlation with other gene mutations and prognostic value. TET2; acute myeloid leukemia; expression; prognosis. Secondary Objective(s) The safety profile of the combination of azacitidine and ascorbic acid in the targeted patient population. Blood. Scopim-Ribeiro R, Machado-Neto JA, de Melo Campos P, Niemann FS, Lorand-Metze I, Costa FF, Olalla Saad ST, Traina F. Diagn Pathol. CNKI, China National Knowledge Internet; AML, acute myeloid leukemia. Aging (Albany NY). 2020 May 25;9(5):1310. doi: 10.3390/cells9051310. doi: 10.1182/blood-2016-08-733196. Cancer Inform. Salmoiraghi S, Cavagna R, Zanghì P, Pavoni C, Michelato A, Buklijas K, Elidi L, Intermesoli T, Lussana F, Oldani E, Caprioli C, Stefanoni P, Gianfaldoni G, Audisio E, Terruzzi E, De Paoli L, Borlenghi E, Cavattoni I, Mattei D, Scattolin A, Tajana M, Ciceri F, Todisco E, Campiotti L, Corradini P, Fracchiolla N, Bassan R, Rambaldi A, Spinelli O. These findings indicated that down-regulation of TET2 expression was a common event and acted as a prognostic and predictive biomarker in CN-AML patients. For patients with intermediate-risk cytogenetics (IR-AML), mutant TET2 had a significant association with … Haladyna JN, Yamauchi T, Neff T, Bernt KM. 2011 Apr 1;29(10):1373-81. doi: 10.1200/JCO.2010.32.7742. CNKI, China National Knowledge Internet; AML, acute…, Prognosis of AML patients with TET2 mutation. Sixteen studies were included. So, the most common mutation in AML is F-L-T-3, FLT3 mutation. TET2 mutations in acute myeloid leukemia: a comprehensive study in patients of Sindh, Pakistan. Background: 2021 Feb 9;9:e10678. vcfView: An Extensible Data Visualization and Quality Assurance Platform for Integrated Somatic Variant Analysis. -. Epub 2020 Oct 21. N Engl J Med. We herein studied the frequency and genotype-phenotype correlation of TET2 gene in AML patients in Sindh, Pakistan. MicroRNA22-5p targets ten-eleven translocation and regulates estrogen receptor 2 expression in infertile women with minimal/mild endometriosis during implantation window. Results: DNMT3A mutation is a poor prognosis biomarker in AML: results of a meta-analysis of 4500 AML patients. Cells. Cells. Ribeiro AF, Pratcorona M, Erpelinck-Verschueren C, et al. Leuk Res. The impact of the allelic burden of ASXL1, DNMT3A, JAK2, TET2, and TP53 mutations on survival remains unclear in patients with newly diagnosed acute myeloid leukemia (AML).. Methods. By … Mutations are also detected in 38% of peripheral T-cell lymphoma and 47% of angioimmunoblastic T-cell lymphoma. Blood 2012; 119:5824. Gaidzik VI, Paschka P, Späth D, et al. TET2 gene mutation had no significant correlation with C-KIT, FLT3, JAK2V617F mutations, but did with NPM1 mutation. J Clin Oncol. BCL3 Expression Is a Potential Prognostic and Predictive Biomarker in Acute Myeloid Leukemia of FAB Subtype M2. Further, among patients with CN-AML, mutant TET2 was associated with inferior OS (HR = 2.034, P < 0.001) and EFS (HR = 2.140, P < 0.001) in the ELN favorable-risk subgroup and an inferior EFS (HR = 1.487; P < 0.001) in the ELN intermediate-Isubgroup. Restoration of TET2 deficiency inhibits tumor growth in head neck squamous cell carcinoma.

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