b lymphocytes slideshare

Other intracellular features help to identify B cells but are not as exclusively characteristic as is gene rearrangement. • Signaling through the pre-B cell receptor induces a few rounds of proliferation; at the end of this the pre-B cell receptor is lost from the surface late pre B cell stage • If pre B cell receptor cannot be displayed on cell surface because of nonproductive VHDJH gene rearrangement, then B cell development stops and the cell undergoes Immune system - Immune system - Activation of T and B lymphocytes: In its lifetime a lymphocyte may or may not come into contact with the antigen it is capable of recognizing, but if it does it can be activated to multiply into a large number of identical cells, called a clone. B Lymphocytes originate in the bone marrow and the lymph nodes while T Lymphocytes originate from the thymus. A lymphocyte is a type of white blood cell that is part of the immune system. B cells, also known as B lymphocytes, are a type of white blood cell of the lymphocyte subtype. B.David Stollar, in Encyclopedia of Immunology (Second Edition), 1998. • Differentiation into mature B lymphocytes • Maturation into plasma cells and memory cells • Various B cell tumors represent different stages in B cell development . In some people with CLL, the disease grows and progresses slowly. The role of lymphocytes involves recognizing harmful particles, or antigens, and carrying out processes to deal with them. RBC carries and transports oxygen while WBC helps in defense mechanisms. Lymphocytes are a type of white blood cell involved in the body’s immune system. Leukemia begins when healthy blood cells change and grow out of control. Intracellular features of B cells. These plasma cells produce antigen-specific antibodies and memory cells which enable the body to rapidly produce antibodies if the same antigen appears later. B- Lymphocytes, which have specific antigen receptors react when they come to contact with the specific antigen by producing plasma cells. B cells produce antibody, molecules, however, these antibodies are not secreted.Rather, they are inserted into the plasma membrane where they serve as a part of B-cell receptors. Depending on life span lymphocytes are classified into short lived (2 weeks) and long lived (3 years or more or even lifelong). Lymphocytes are divided in two parts, B Lymphocytes and T Lymphocytes, also known as B cells and T cells. The function of both these lymphocytes is to protect the body against infection and are necessary components of our immune system. Different types of lymphocytes exist, known as T cells, B cells and natural killer cells, and their roles differ accordingly. Chronic lymphocytic leukemia (CLL) is a cancer of the lymphocytes. B cells are antigen specific. According to side lymphocytes are divided into small (5-8µm), medium (8-12µm) and large (12-15µm). Lymphocytes represent 20-45% of total cells in peripheral blood and 99% of total cells in lymph and lymph node. They function in the humoral immunity component of the adaptive immune system. A defining feature of B lymphocytes is that they are the only cells that rearrange chromosomal DNA in the loci that code for antibodies (immunoglobulins). The main two types of cells in blood are red blood cells (RBC) and white blood cells (WBC). Humoral immune response is also called B-cell mediated immunity because B-lymphocytes are involved in this response. Leukemia is a cancer of the blood. Humoral immune response is to defend the body against pathogens that may invade body fluids or humor. The key difference between T lymphocytes and B lymphocytes is that the T lymphocytes originate in bone marrows and mature in the thymus while B lymphocytes originate and mature in bone marrows..

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