cytotoxic t cells definition

n. See killer cell. Residues 11 to 27 of the hepatitis B virus nucleocapsid antigen contain a cytotoxic T-cell epitope that is recognized by cytotoxic T cells from virtually all HLA-A2-positive patients with acute hepatitis B virus infection. Definition. The CD8+ CTL response was critical for resolving this infection, since beta 2-microglobulin knockout (CD8-deficient) mice were unable to control the LCMV Armstrong infection and became persistently infected. Using panels of truncated Cytotoxic T-lymphocyte: A T cell that is antigen-specific and is able to search out and kill specific types of virus-infected cells. Suppressor T cells are sensitive to high concentrations of circulating lymphokine hormones, and release their own lymphokines after an immune response has achieved its goal. Synonyms . Cross-priming, the result of this process, describes the stimulation of naive cytotoxic CD8 + T cells into activated cytotoxic CD8 + T cells. 1 English. Noun . CTL - cytotoxic T cell. Jump to navigation Jump to search. The research team found that antigen-specific T-cell receptors in the human immune system may react with drugs, mistaking them for invading pathogens, and activate cytotoxic T cells, which produce proteins that attack the mistaken pathogens and bring collateral damage to healthy cells, leading to drug allergies. Also known as CD8+ cells, because of a protein that they express on their … Key Terms: Antigen Presenting Cells, Cytotoxic T Cells, Endogenous Antigens, Exogenous Antigens, HLA, Helper T Cells, MHC (major histocompatibility complex) What is … cytotoxic T cell (plural cytotoxic T cells) A subtype of T cell, capable of inducing death in infected somatic or tumor cells. Because the body contains millions of T and B cells, many of which carry unique receptors , it can respond to virtually any antigen. Definition. cytotoxic T-cell a specialized T-cell which recognizes and destroys infected body cells during a cell-mediated immune response. The main difference between NK cells and NKT cells is that NK cells are large granular lymphocytes while NKT cells are a type of T cells. As the name suggests regulatory T cells (also called Tregs) are T cells which have a role in regulating or suppressing other cells in the immune system. Meanwhile CD4+ … Definition from Wiktionary, the free dictionary. The doctor found vitamin C had a cytotoxic effect on cancer cells and reduced their number. Cytotoxic T cells refer to a type of immune cell that can kill certain cells, including foreign cells, cancer cells, and cells infected with a virus. Helper T cells play a central role in normal immune responses by producing factors that activate virtually all the other immune system cells. Dendritic Cells Play a Major Role in the Induction of CD8 + T Cell Responses. They efficiently recognize and destroy virus-infected host cells or tumor cells, which expose antigenic peptides bound to major histocompatibility complex (MHC) class I molecules. This signals all other immune-system … Cytotoxic T cells refer to a type of immune cell that can kill certain cells, including foreign cells, cancer cells, and cells infected with a virus. The mechanism is unclear, but extrapolating from familial form, deranged cytokine interaction between histiocytes, Dictionary, Encyclopedia and Thesaurus - The Free Dictionary, the webmaster's page for free fun content, The In Vivo Dynamics of HIV Infection with the Influence of Cytotoxic T Lymphocyte Cells, Tap: novel targets for cancer vaccine development, GERON REPORTS NET LOSS OF $9.7 MILLION FOR FIRST QTR 2005, Two strategies for protecting poultry from Coccidia, Corvus Pharmaceuticals announces preclinical data from CPI-818 study, Immunicum ends enrolment of Phase I/II GIST clinical trial, Mesenchymal stem cell therapy for cardiac inflammation: immunomodulatory properties and the influence of toll-like receptors, Epstein-barr virus in systemic autoimmune diseases, Renal cell carcinoma with secondary hemophagocytic syndrome: A case report, cytotoxicity, antibody-dependent cell-mediated, Cytotoxic T Lymphocyte-Associated Antigen 4, Cytotoxic T-Lymphocyte Precursor Frequency, Cytotoxic T-lymphocyte-associated antigen 8, cytotoxic T-lymphocyte-associated protein, Cytotoxic T-Lymphocyte-Associated Protein 4, cytotoxic T-lymphocyte-associated protein 8, cytotoxic T-lymphocyte-associated serine esterase 8. Cytotoxic T cells also secrete cytokines like IL-2 and IFN-γ, which regulate the effector functions of other immune cells. Cytotoxic T cell A cytotoxic (or TC) T cell is a T cell (a type of white blood cell) which has on its surface antigen receptors that can bind to fragments of antigens displayed by the Class I MHC molecules of virus infected somatic cells and tumor cells. CD8+ T cells with an effector phenotype express cytotoxic molecules and are able to perform target cell killing. Cytotoxic T cells (also called CD8+ T cells) - are involved in the direct destruction of cells that have become cancerous or are infected by a pathogen. All content on this website, including dictionary, thesaurus, literature, geography, and other reference data is for informational purposes only. They efficiently recognize and destroy virus-infected host cells or tumor cells, which expose antigenic peptides bound to major histocompatibility complex (MHC) class I molecules.

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