rbc disorders slideshare

Types of blood disorders … Normal mature RBC are biconcave, round discs that are about 6 – 8 in diameter, which is only slightly smaller than the normal small mature lymphocytes ( about 6 – 10 in diameter). Increased shedding of RBC vesicles, for example, is a feature of various RBC pathologies and vesicles are increasingly being considered to be a novel biomarker of RBC disorders (Pattanapanyasat et al., 2004; Nantakomol et al., 2012; Alaarg et al., 2013). Hereditary spherocytosis is a genetic disorder, a molecular defect in one or more of the proteins of the red blood cell cytoskeleton, including, spectrin, ankyrin, Band 3, or Protein 4.2. Hemoglobinopathies are a group of rare, inherited disorders involving abnormal structure of the hemoglobin molecule. Hemoglobin Derivatives 4. Other causes include other diseases, side effects of medicines, and a lack of certain nutrients in your diet. Microcytosis: RBCs smaller than the normal size are considered as microcytes. The term used to indicate red blood cells of normal size and shape is normocytic. As a compensatory mechanism, there is increased red blood cell (RBC)production by the bone marrow. ; In men, anemia is typically defined as a hemoglobin level of less than 13.5 gram/100 ml and in women as hemoglobin of less than 12.0 gram/100 ml. Anisocytosis is divided into Macrocytosis and Microcytosis. What are red blood cell disorders? ADVERTISEMENTS: Let us make an in-depth study of the hemoglobin. Introduction to Hemoglobin: It is an oxygen/CO2 carrier protein present in the red blood […] Composition of Hemoglobin 3. Biochemistry of Abnormality in the Hemoglobin. Because the cell skeleton has a defect, the blood cell contracts to its most surface-tension efficient and least flexible configuration, a sphere. There are multiple disorders of the red blood cells, including hemoglobinopathies, cytoskeletal abnormalities (spherocytosis and other membranopathies) and enzymopathies. RBC count, Hematocrit/ Packed cell volume (PCV), Hemoglobin (Hb), Mean corpuscular Volume (MCV), Mean corpuscular haemoglobin (MCH), Mean corpuscular haemoglobin concentration (MCHC), RDW, Reticulocyte count. Anemia can occur either due to a decreased RBC count, decreased hemoglobin or the decreased blood volume. The page below is a sample from the LabCE course Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions. Learn more about Red Cell Disorders: Peripheral Blood Clues to Nonneoplastic Conditions (online CE course) When a complete blood count is advised, the following tests related to RBCs are done. Introduction to Hemoglobin 2. Microcytosis is seen in : Iron deficiency anemia, thalassemia, lead poisoning, sideroblastic anemia and anemia of chronic disorders. There is a range of different types and symptoms depend on the type. Nucleus of small lymphocyte is useful guide to the size of RBC. Blood disorders are conditions that impact the blood’s ability to function correctly. Types of Hemoglobin and 5. Access the complete course and earn ASCLS P.A.C.E.-approved continuing education credits by subscribing online. Blood disorders affect one or more parts of the blood and prevent your blood from doing its job. Table 1: General features of a mature RBC. “Anaemia is an+aemia (no+blood).It is a condition wherein there is decreased oxygen-carrying capacity by the blood.” Red blood cells carry oxygen to different parts of the body. After reading this article you will learn about 1. They can be acute or chronic. In hemolytic disorders,the normal life span of erythrocytes inthe peripheral blood of 120 days is substantially shortened because of red celldestruction. They have an iron pigment namely hemoglobin to do that.. Anemia is a medical condition in which the red blood cell count or the hemoglobin is less than normal. Many blood disorders are inherited.

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