role of platelets in hemostasis slideshare

A glycoprotein (GP) complex, IIb/IIIa, is found in abundance in the platelet cell membrane as a surface receptor. The main function of platelets is a responsibility in the formation of blood clots during hemostasis. Sepsis is caused by a dysregulated host response to infection; therefore, the role of platelets in sepsis should also reflect the now established role of platelets in the immune response. Platelets are small anucleate cell fragments that circulate in blood playing crucial role in managing vascular integrity and regulating hemostasis. 3.Describe Platelets were discovered by G. Bizzozero in 1882 and rediscovered in the 1960s after many decades of oblivion. Platelet aggregates, stabilized by fibrin, rapidly form hemostatic plugs when blood vessels are severed or arterial thrombi at sites of vessel injury, such as ruptured atherosclerotic plaques, or regions where blood flow is disturbed, such as at stenoses. The current communication addresses unresolved questions about the role of hemostasis, in particular the role of fibrinogen and platelets, in mammalian development and reproduction. Platelets play a key role in normal hemostasis and abnormal thrombosis. These thrombi cause the thromboembolic compl … Hemostasis “Hemostasis is a physiological defensive reaction to an injury or a cut that seals the blood vessels and thus helps in healing.” Mainly platelets, endothelial cells of blood vessels, and blood proteins are responsible for hemostasis. the objectives from this ppt :- 1.Define haemostasis. 5 PLATELETS IN THE IMMUNE RESPONSE. 2.Describe the main mechanisms that prevent blood loss after an injury. Platelets in hemostasis. : Platelet-activation mechanisms and role of the PY 12 receptor. Platelet hyperaggregation among the … [ ]. Interestingly enough, their role was initially more clearly associated with thrombosis than with hemostasis. Platelet Function. For many years a serious unresolved problem was that the clotting time was norm … The complex is Ca 2+ dependent, and the primary structural sequence of its components has been determined by cloning. This is the most common and often described role of the blood component, whereas the remaining functions remain less known. Platelets are small anuclear cell fragments that circulate in the blood. Platelets are also involved in the fundamental biological process of chronic inflammation associated with disease pathology. Platelet activation leads to dense-granule secretion of ADP, which activates PY 12, inducing ampli cation of aggregation, procoagulant, and proinammatory responses (adapted from Storey, [ ]). Thus the platelets help in blood coagulation. The Three Steps of Hemostasis Primary Hemostasis Interaction between vessel wall, platelets and adhesive proteins platelet clot Coagulation Consolidation of the platelet thrombus insoluble fibrin net • Coagulation factors and inhibitors Fibrinolysis Clot lysis clot is digested • … The role of platelets in sepsis was first investigated in terms of their significant role in hemostasis and thrombosis.

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